MECHANISTIC INSIGHTS OF LENVATINIB: ENHANCING CISPLATIN SENSITIVITY, INDUCING APOPTOSIS, AND SUPPRESSING METASTASIS IN BLADDER CANCER CELLS THROUGH EGFR/ERK/P38/NF-κB SIGNALING INACTIVATION

Abstract Background The persistent activation of the epidermal growth factor receptor (EGFR) leads to the activation of downstream oncogenic kinases and transcription factors, resulting in tumor progression and an increased resistance to cisplatin in bladder cancer (BC) cells.Lenvatinib, an oral multikinase inhibitor, has the potential to offer the

IntroductionThe aim of this study was to comprehensively review existing treatments for impulsivity and compulsivity in non-substance addictions, driven by the importance of these factors in addictive disorder development and treatment efficacy.MethodsA systematic review carried out following PRISMA guidelines identified 14 articles from Turmeric a

The influence of energetic factors upon surface properties of suspensions on the basis of Na-CMC with aluminum powder, used Bioflavonoids to produce anticorrosion coatings, is revealed.It is shown that relative adhesion work, got by measuring the extent of suspensions Face Masks surface strain and the angles of wetting the steel surface with suspen

The kang-stove system (KSS) is a combination cooking and heating system and is the core element of the living space of many rural houses in northern China.The traditional KSS is usually single kang model (SKM) that one stove combines with one kang, Round Cake Pans which causes inconveniences including an insufficient room heating supply, a small he

Abstract Women whose sexuality deviate from the heteronormative standard, such as lesbians and bisexuals, go unnoticed by health services.This study aims to describe the experiences of discrimination suffered by a lesbian woman with breast cancer and her partner during their oncological treatment journey.A qualitative case study based on in-depth i